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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T8452 | Dantrolene | Others | |
Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. | |||
T9998 | MIND4-19 | Sirtuin | |
MIND4-19 is an inhibitor of SIRT2 with antitumor activity. | |||
T6111 | Selisistat | EX-527,SEN0014196 | Sirtuin |
Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM). Selisistat can be used in the study of neurological disorders such as Huntington's chorea. | |||
T9159 | PBT-1033 | PB 1033,PBT1033,PBT-2,PBT 2,PBT2 | Others |
PBT-1033 (PBT-2) is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease. | |||
T22595 | B2 | Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline | Others , Sirtuin |
B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease | |||
T62839 | Dalzanemdor | SAGE-718 | NMDAR , iGluR |
Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction. | |||
T38605 | NCT-504 | Others | |
NCT-504, a selective allosteric inhibitor of PIP4Kγ, exhibits an IC50 value of 15.8 μM. It holds promise for the investigation of Huntington's disease. | |||
T23331 | SC 51089 | SC 51089 free base | Prostaglandin Receptor |
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's... | |||
T61859 | MK-28 | Antiviral , PERK | |
MK-28 is a selective PERK agonist that reduces toxicity and prolongs survival in a Huntington's disease model.MK-28 has a significant killing effect on MK28 gastric cancer cells. | |||
T2075 | Pyrazolo[1,5-a]pyrimidine 4h | Others | |
Pyrazolo[1,5-a]pyrimidine 4h is a morpholine derivative that is a selective antagonist of the adenosine A2A receptor. It has been shown to be neuroprotective in animal models of Parkinson's disease and Huntington's chore... | |||
T9340 | 1-phenyl-3,4-dihydroisochinoline | 3,4-Dihydro-1-phenylisoquinoline | Others |
1-phenyl-3,4-dihydroisochinoline (3,4-Dihydro-1-phenylisoquinoline) is a structural analog of the neurotransmitter dopamine that interacts with dopamine receptors in the central nervous system. It has been studied as a p... | |||
T13133 | Tetrabenazine Metabolite | (-)-β-Dihydrotetrabenazine,(-)-β-HTBZ | Monoamine Transporter |
Tetrabenazine Metabolite ((-)-β-HTBZ), a vesicles monoamine transporter 2 (VMAT2) inhibitor, is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite has a high affinity for VMAT2 with a Ki of 13.4 nM. Tetraben... | |||
T40652 | Meclizine | Meclozine | Histamine Receptor |
Meclizine, also known as Meclozine, is a piperazine class H1 antagonist with antihistamine properties that inhibits the interaction of histamine at H1 receptors reversibly. It serves as an effective anti-motion sickness ... | |||
T28363 | PF-02545920 | ||
PF-02545920, a PDE10 inhibitor, is used potentially for the treatment of Huntington's Disease. | |||
T33895 | PBT-1033 hydrochloride | PBT 1033,PBT2,PBT 2,PBT-2,PBT1033,PBT-1033 | |
PBT-1033 hydrochloride is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease. | |||
T39480 | Lexanersen | WVE-120102,Lexanersen | |
Lexanersen (WVE-120102), an antisense oligonucleotide, is utilized in Huntington's disease research. | |||
T40843 | 1-(Anilinocarbonyl)proline | ||
1-(Anilinocarbonyl)proline is a compound utilized for identifying dual-action probes within a cell model of Huntington's disease. | |||
T69441 | NSC66098 | ||
NSC66098 is a novel potent inhibitor of Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein. | |||
T71969 | Remacemide | ||
Remacemide is a low-affinity NMDA antagonist with sodium channel blocking properties. It has been studied for the treatment of acute ischemic stroke, epilepsy, Huntington's disease, and Parkinson's disease. | |||
T34662 | SMER10 | SMER-10,SMER 10 | |
SMER10 is an enhancer of the clearance of mutant aggregate-prone proteins by autophagy in mammalian cell models of Huntington's and Parkinson's disease, independent of rapamycin. | |||
T26683 | AUTEN-67 | Autophagy enhancer 67,MTMR14 inhibitor,AUTEN67 | |
AUTEN-67 is a specific inhibitor of MTMR14 and autophagy enhancer with potent antiaging and neuroprotective effects. AUTEN-67 also delays the onset and decreases the severity of Huntington's disease. | |||
T79865 | Votoplam | DNA/RNA Synthesis | |
Votoplam functions as a gene splicing modulator, employed in the inhibition of Huntington's disease [1]. | |||
T80813 | WAY-354574 | Sirtuin | |
WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1]. | |||
T7352L | Pridopidine hydrochloride | ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride | |
Pridopidine Hydrochloride is a dopaminergic stabilizer that has been shown to improve a variety of neurological and psychiatric disorders, including Huntington's disease. Pridopidine Hydrochloride stabilizes psychomotor ... | |||
T38279 | C2-8 | C2-8 | |
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isola... | |||
T38146 | Chloroguanabenz (acetate) | ||
Chloroguanabenz is an antiprion agent and a derivative of the α2-adrenergic receptor agonist guanabenz . It inhibits prion formation in yeast and mammalian cell-based assays. Chloroguanabenz reduces the levels of both so... | |||
T61497 | Rho-Kinase-IN-2 | ||
Rho-Kinase-IN-2 (Compound 23) is an orally active and selective inhibitor of Rho Kinase (ROCK), which can penetrate the central nervous system (CNS). It exhibits a high affinity for ROCK2 with an inhibition constant (IC5... | |||
T79038 | Tau protein aggregation-IN-1 | ||
Tau Protein Aggregation-IN-1 (Compound 0c) serves as an inhibitor of Tau protein aggregation, applicable in research related to protein folding disorders including Alzheimer's disease, dementia, Parkinson's disease, Hunt... | |||
T61991 | HTT-D3 | ||
HTT-D3 is a potent and orally active huntingtin (HTT) splicing modulator. HTT-D3 can lead to HTT mRNA degradation and reduction of HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux, and has research value in Huntin... | |||
T73289 | MHTT-IN-1 | ||
mHTT-IN-1 (Example 1) is a potent inhibitor of the mutant huntingtin protein (mHTT), which is toxic and primarily responsible for Huntington's disease (HD), an inherited autosomal dominant neurodegenerative disorder. Thi... | |||
T74247 | TPE-MI | ||
Tetraphenylethene maleimide (TPE-MI) serves as a thiol probe to assess unfolded protein levels and proteostasis within cells. It is particularly effective in identifying proteostasis imbalances in both induced pluripoten... | |||
T83947 | HDAC4 CHDI Degrader 11 | ||
HDAC4 CHDI Degrader 11 is a potent, selective degrader of HDAC4 (PROTAC) with DC_50 values of 4 nM and 6 nM in Jurkat E6-1 and Jurkat cells, respectively. This compound integrates the class IIa HDAC inhibitor trifluorome... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-01355 | Transglutaminase 2/TGM2 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth an... |